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KMID : 0613820200300050468
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Journal of Life Science
2020 Volume.30 No. 5 p.468 ~ p.475
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Antioxidant Activity and Cell Differentiation Effects of Monascus purpureus Pigment on Osteoblast-like MC3T3-E1 Cells
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Kim Bo-Kyung
Ryu Ji-Hye
Jang Seok-Oui
Kim Mi-Hyang
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Abstract
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The purpose of this study was to investigate antioxidant activity and cell differentiation effects of Monascus purpureus pigment on osteoblast-like MC3T3-E1 cell. In order to examine the antioxidant activities of Monascus purpureus pigment, DPPH radical scavenging, ABTS radical scavenging and SOD- like activities were investigated. DPPH radical and ABTS radical scavenging activities of Monascus purpureus pigment were increased in a dose-dependent manner, and maximum activity were 94% and 99% at a concentration of 1,000 μg/ml, respectively. Additionally, SOD-like activity of Monascus purpureus pigment showed 62% at a concentration of 1,000 μg/ml. MC3T3-E1 cells did not show cytotoxicity in the concentration range of Monascus purpureus pigment 1~100 μg/ml. The ALP activity was increased by addition of Monascus purpureus pigment, and the maximum activity was 124% as compared with control. In addition, nodule formation, a late differentiation factor for bone formation, was increased by adding Monascus purpureus pigment compared to control. These results suggest that Monascus purpureus pigment is expected to be a natural source for developing functional materials to prevent bone-related diseases by osteoblast differentiation.
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KEYWORD
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Antioxidant, bone formation, Monascus purpureus pigment, osteoblast differentiation
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